Diabetes patients have to endure the pain of repeated injections of insulin, and a new invention from North Carolina State University (UNC) may end this torture. The researchers created the first "smart insulin paste", a thin, coin-less smart sticker filled with more than 100 eyelash-sized "micro-needle" filled with tiny amounts of insulin when blood sugar levels are too high It can sense and release insulin quickly. The study, published in the Proceedings of the National Academy of Sciences, found that the new painless patch can last up to 9 hours in mice with type 1 diabetes. Although smart stickers require more clinical trials before being used in patients with diabetes, it has shown great promise. Diabetes affects 387 million people worldwide, and this number will increase to 592 million by 2035. People with type I and type II diabetes need regular blood tests to check blood sugar levels and inject insulin, a process that is painful but not very precise. Injecting the wrong dose of the drug can cause blindness, amputation, coma, and even death. The author of the paper, Dr. Gu Zhen, a professor of UNC biomedical engineering, said that this painless smart sticker made of non-toxic biocompatible materials can be easily and quickly used to treat diabetic patients individually. According to a report by the Physicist Network on the 23rd, in order to eliminate possible human error, the researchers created a "closed loop system" to establish a direct link between blood glucose testing equipment and insulin control equipment. They mimic the workings of "human natural insulin generators" beta cells - producing and storing insulin in small vesicles, sensing the increase in blood glucose levels like an alarm center and releasing signals to release insulin. The function of artificial vesicles relies on two natural materials that are easy to find: hyaluronic acid (HA), which contains many natural ingredients; second, an organic compound commonly used in diagnosis, 2-nitroimidazole Class (NI). They combine the two materials into a new molecule with one end hydrophilic and one hydrophobic. Many of these molecules mix and self-assemble into a vesicle that is 100 times smaller than the width of human hair, in which solid insulin and enzymes that specifically sense glucose are inserted. When blood sugar rises, glucose enters the artificial vesicles, and the enzyme converts gluconic acid to consume oxygen. The hypoxia makes the hydrophobic NI molecules hydrophilic, and the vesicles rupture and push the insulin into the subcutaneous capillaries. Since mice are not as sensitive to insulin as humans, the researchers believe that if you experiment on patients, "smart insulin paste" may last longer to maintain blood sugar levels. Their goal is to have patients change their stickers for a few days. Anti-Aging Masterbatch, also name UV Masterbatch,makes through optimization of composite processed by selecting efficient light stabilizer and antioxidant, used in plastic processing of PE,PP,ABS, can effectively reduce the heating oxidation caused the explanation effect in plastic products processing, and greatly relieved degradation caused by ultraviolet light irradiation in plastic products using processing, then significantly improve the anti-aging properties of plastic products, prolonging the service life. Anti-Aging Masterbatch,Anti-Aging Masterbatch Granules,Anti-Aging White Masterbatch,Stability Anti-Aging Masterbatch Cai Jian Plastic Product Co., Ltd. , http://www.caijianmasterbatch.com