However, with the improvement of living standards and the strengthening of health awareness, the problems of drug resistance and drug residues caused by feed antibiotics have also received increasing attention. Governments have introduced measures to strictly control antibiotics as feed additive applications. China's Ministry of Agriculture said in 2011 that it plans to ban the addition of antibiotics to animal feed in order to increase consumer trust in livestock products. At the end of March this year, the US court ruled that the use of antibiotics in feed was completely banned. Therefore, the development of antibiotic substitutes has become a hot spot in feed additive research. Sodium butyrate can be used as one of the antibiotic substitutes Short chain fatty acids (SCFA) include acetic acid, propionic acid, and butyric acid, of which the main role is butyric acid. It is mainly derived from the enzymatic hydrolysis of carbohydrates and proteins by anaerobic bacteria in the large intestine and is the main source of energy for colonic epithelial cells. As a biological regulator, butyric acid plays an important role in maintaining cell differentiation and colonic epithelial integrity and improving animal performance. Because of its free and volatile characteristics, it is made into a relatively stable sodium salt, sodium butyrate, in feed production. Sodium butyrate has become one of the most potential animal health products and antibiotic substitutes because of its non-polluting, no harmful residues and unique nutritional and physiological functions. Sodium butyl physicochemical properties The sodium butyrate product is white to off-white, hygroscopic powder, fluffy, with a special rancid-like odor of cheese, soluble in water, and the pH of the aqueous solution is alkaline. This product is stable under room temperature and sealed conditions under normal storage and handling conditions, but should not be mixed with substances of opposite nature, dust, overheated materials and strong oxidants. This product may produce harmful decomposition products such as carbon monoxide, carbon dioxide, sodium oxide, allergenic and toxic fumes and gases, and may also cause central nervous system depression, eye and skin allergies, digestive tract and respiratory stress. Industrial grade sodium butyrate can not be used in feed Feed grade sodium butyrate is significantly different from chemical grade sodium butyrate. The oral mucosa of animals is soft and sensitive. If low-grade, low-quality chemical grade sodium butyrate is used as an attractant, it can cause animal mucosal burns, resulting in decreased feed intake and even refusal. Nutritional physiological function of sodium butyrate 1 is the main source of energy for colonic mucosal epithelial cells. Butyric acid is the preferred energy of intestinal cells. Sodium butyrate is absorbed in the intestinal lumen and can rapidly supply energy to intestinal epithelial cells through oxidation. It can directly supply energy to intestinal epithelial cells without undergoing hepatobiliary absorption and complex trihydroxy circulatory system, and is a rapid energy source for intestinal epithelial cells. 2 Improve the shape of the small intestine and promote the digestion and absorption of the small intestine. Promote the proliferation and maturation of gastrointestinal cells, the digestive tract of young animals is imperfect, the development of intestinal villi and crypts is immature, and the secretion of digestive enzymes is not enough, resulting in poor absorption of nutrients in juvenile animals. Tests have shown that sodium butyrate is an activator that increases intestinal villus proliferation and crypt deepening, and can expand the intestinal absorption area. 3 Maintain the normal morphology of intestinal mucosal epithelial cells and enhance the immune function of animals. 4 It has the function of bactericidal and anti-bacterial, maintains the beneficial microbial flora in the gastrointestinal tract, and the butyric acid inhibits the growth of harmful bacteria (Salmonella, Escherichia coli, Clostridium, etc.) through the cell membrane, and promotes beneficial bacteria in the gastrointestinal tract (Lactobacillus, The growth of Streptococcus faecalis, etc., makes the gastrointestinal micro-ecology in a positive balance, improves the intestinal microflora, reduces animal diarrhea, and plays a part in replacing antibiotics. 5 Sodium butyrate has a characteristic odor and can induce animal feeding. Young animals after weaning remain dependent on maternal material in the diet. Pig milk contains more than 3.8% butyrate in dry matter. Therefore, the role of sodium butyrate in piglet feed and ruminant milk replacer is particularly evident. Fire Pump Set,Electric Fire Pump Set,Dual Fire Pump Set,Vertical Turbine Fire Pump Set Shanxi Skysea Pump Lndustry Co.,Ltd. , https://www.skyseatianhai.com